Number of randomized patients:

103

Number of recruiting sites:

22

Key inclusion criteria

1. Informed consent as documented by signature
2. Age ≥ 18 to < 86 years
3. Acute ischemic stroke (AIS)
4. NIHSS ≥ 8 and < 30
5. Patient is eligible for IV t-PA
6. Patient is eligible for endovascular therapy
7. Randomization no later than 4 hours 15 minutes after stroke symptom onset and initiation of IV t-PA must be started within 4 hours 30 minutes of stroke symptoms onset
8. Occlusion (TICI 0-1) of the intracranial internal carotid artery (ICA) , M1 segment of the middle cerebral artery (MCA), or both confirmed by CT or MR angiography, accessible for MT
9. ASPECTS score greater ≥ 6

Key exclusion criteria

1. Acute intracranial hemorrhage
2. Any contraindication for IV t-PA
3. Pre-treatment with IV t-PA
4. In-hospital stroke
5. Pregnancy or lactating women
6. Known (serious) sensitivity to radiographic contrast agents, nickel, titanium metals or their alloys
7. Current participation in a clinical trial
8. Renal insufficiency
9. Life expectancy less than 90 days at baseline
10. Known advanced dementia or significant pre-stroke disability (mRS score of ≥ 2)